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作者观察了拟除虫菊酯对大鼠脑突触体谷氨酸重摄取功能的影响。在一定量的突触体与不同剂量的氯氰菊酯或氯菊酯中加入放射性标记谷氨酸，测定突触体摄取的谷氨酸的放射活性，在１０－ ９ ～１０－ ４ ｍ ｏｌ／ Ｌ的剂量范围内，氯氰菊酯及氯菊酯明显抑制突触体对谷氨酸的重摄取量，并有一定的剂量依赖性。在相同剂量水平，氯氰菊酯作用明显强于氯菊酯。结果表明拟除虫菊酯对大鼠脑突触体谷氨酸高亲和性重摄取功能有抑制作用，提示突触体谷氨酸重摄取系统功能障碍在拟除虫菊酯兴奋性神经毒性中具有重要意义。
The authors observed the effect of pyrethroids on glutamate uptake in rat brain synaptosomes. In a certain amount of synaptosomes and different doses of cypermethrin or permethrin radioactively labeled glutamic acid, measured by the synaptosomal uptake of glutamate radioactivity in 10- 9 ~ 10-4mol / L Within the dose range, cypermethrin and permethrin significantly inhibited the reuptake of glutamate by synaptosomes in a dose-dependent manner. At the same dose level, cypermethrin was significantly stronger than permethrin. The results showed that pyrethroid inhibited glutamate-induced high-affinity reuptake in rat brain synapses, suggesting that dysfunction of glutamate reuptake system in synaptosomes is of great importance in the neurotoxicity of pyrethroids .