论文部分内容阅读
Dubin和Johnson二氏于1954年首先描述本综合征后,欧美日相继报导已达200余例。国内1958年报导5例后,迄今已有34例,开始均曾误诊为“病毒性肝炎”,最后均经组织学检查证实为本征。本例误诊12年,有些临床表现虽类似病毒性慢性肝炎,但肝功能检测仅血清结合胆红质水平一项增高,血清乙肝病毒标志物(HBVM)全部阴性,超微结构发现肝细胞溶酶体内有特异色素颗粒沉着,乃证实诊断。服苯巴比妥后,症状缓解甚显著。从误诊中吸取了一定的经验教训,并对其病因机理和电镜所见予以阐述。
After Dubin and Johnson first described the syndrome in 1954, Europe, the United States and Japan have reported more than 200 cases in succession. After the report of 5 cases in China in 1958, there have been 34 cases so far, all of them have been misdiagnosed as “viral hepatitis” at the beginning, and the results have been confirmed by histological examination. Misdiagnosis of 12 cases in this case, although some of the clinical manifestations of similar viral chronic hepatitis, but liver function test only serum bilirubin level increased, all of the serum hepatitis B virus markers (HBVM) were negative, ultrastructural findings of hepatolysin Pigmentation of the body with specific pigment, but confirmed the diagnosis. After taking phenobarbital, the symptoms were relieved. Draw lessons from misdiagnosis, and explain its etiology and electron microscopy.