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丙吡胺(Disopyramide)是一抗心律失常药,药理及临床研究发现有类似奎尼丁的抗心律失常作用。且安全范围较大。为测定本品在体液中的浓度,我们建立了高效液相色谱法。丙吡胺的血药浓度测定方法,据报道有:酶免疫测定法、薄层层析扫描法、高效液相色谱法。本文采用高效液相色谱法,用waters 840、490液相色谱仪测定,筛选出普鲁卡因酰胺做内标,最低检出浓度为0.5μg/ml。
Disopyramide is a primary antiarrhythmic drug and pharmacological and clinical studies have found anti-arrhythmic effects similar to quinidine. And a larger security range. To determine the concentration of this product in body fluids, we established a high performance liquid chromatography. Determination of plasma concentration of disopyramide, according to reports are: enzyme immunoassay, TLC scanning, high performance liquid chromatography. In this paper, high performance liquid chromatography with waters 840,490 liquid chromatography determination of procaine amide as an internal standard, the minimum detectable concentration of 0.5μg / ml.