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目的探讨高危型人乳头瘤病毒(HR-HPV)检测在宫颈病变治疗后随访的临床价值。方法选择2006年1月至2010年12月在阳江市妇幼保健院宫颈病诊治中心经HR-HPV,液基细胞学(TCT),阴道镜定位下活检病理结果为确诊≥CINⅡ,接受宫颈锥切术(LEEP)252例患者的临床资料进行回顾性分析,对术前术后随访HR-HPV变化以病变残留、复发情况进行动态观察分析。结果术前高度宫颈病变HR-HPV阳性率达96%,术后HR-HPV转阴率91.66%,手术切缘阳性或复发患者HR-HPV感染率明显高于手术切缘阴性患者感染率,术后HR-HPV阳性患者的复发率高。结论 HR-HPV具有较高阴性预测值,术后HR-HPV转阴性患者愈合良,高危型人乳头瘤病毒在宫颈病变治疗后随访中是一项重要指标。
Objective To investigate the clinical value of high-risk human papillomavirus (HR-HPV) testing in the follow-up of cervical lesions. Methods January 2006 to December 2010 in Yangjiang City, Maternal and Child Health Hospital cervical disease diagnosis and treatment centers by HR-HPV, liquid-based cytology (TCT), colposcopy biopsy pathology results confirmed for the diagnosis of ≥ CIN Ⅱ, accept conization of the cervix The clinical data of 252 patients with LEEP were analyzed retrospectively. The changes of HR-HPV before and after the operation were analyzed by dynamic observation of residual disease and recurrence. Results The positive rate of HR-HPV in preoperative high cervical lesions was 96%, and the negative rate of HR-HPV in postoperative patients was 91.66%. The HR-HPV infection rate in patients with positive or recurrent surgical margin was significantly higher than that in patients with negative surgical margin Post-HR-HPV-positive patients have a high recurrence rate. Conclusions HR-HPV has a high negative predictive value. Hepatic HR-HPV negative patients healed well and high-risk human papillomavirus was an important index in the follow-up of cervical lesions.