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流感是一种全球性的传染性疾病,每年造成数十万人的死亡。而流感新亚型的出现,则可能造成流感大爆发,后果更严重。抗流感药物对于流感的预防和治疗具有重要作用,尤其是神经氨酸酶抑制剂对甲、乙型流感病毒均有效,且具有很好的安全性和耐受性,因此在临床中得到广泛应用,但同时也出现了一些耐药性报道。本文介绍了扎那米韦、奥塞米韦和帕拉米韦等抗流感神经氨酸酶抑制剂对于流感的预防和治疗作用、耐药性及其机制,以及国内研发和使用现状,以期促进新型抗流感药物的研发。
Flu is a global contagious disease that causes hundreds of thousands of deaths each year. The emergence of new subtypes of influenza may result in a major outbreak of influenza with more serious consequences. Anti-influenza drugs for the prevention and treatment of influenza has an important role, in particular neuraminidase inhibitors of influenza A and B are effective, and has good safety and tolerability, it is widely used in clinical , But there have also been some reports of drug resistance. This article describes the anti-influenza neuraminidase inhibitors such as zanamivir, oseltamivir and peramivir for the prevention and treatment of influenza, drug resistance and its mechanism, as well as the status of domestic research and development and use, with a view to promoting Development of a new anti-influenza drug.