目的通过对双硫仑样反应的分析,探讨服用部分药物所引起的不良应与乙醇的关系。方法对18例服用抗生素期间饮用乙醇或含有乙醇饮料者出现的不良反应者进行分析。结果 18例均诊断明确,其中11例静滴头孢菌素后2-7h饮酒,7例静滴头孢菌素后7～90h饮酒,饮酒后10～45min出现双硫仑样反应。主要表现皮肤潮红、心悸、呼吸急促及烦躁不安、恶心、呕吐及多汗、胸闷、气短、晕厥伴低血压者、休克等。可以有心电图异常改变。入院后及时给予吸氧,重者静注地塞米松5～10mg,静脉补液促排,低血压及休克者加大糖皮质激素用量并扩容,静注纳洛酮等,全部治愈。结论医务工作者在诊治过程中一定要注意详细交代用药注意事项,杜绝本症的发生。 Objective To analyze the disulfiram-like reaction to explore the relationship between alcohol and the adverse reactions caused by taking some drugs. Methods 18 patients who received alcohol or alcoholic beverages during the course of taking antibiotics were analyzed for their adverse reactions. Results 18 cases were diagnosed, of which 11 cases of intravenous cephalosporins after drinking 2-7h, 7 cases of intravenous cephalosporins 7 ~ 90h drinking, drinking 10 ~ 45min disulfiram-like reaction. The main performance of the skin flushing, palpitations, shortness of breath and irritability, nausea, vomiting and sweating, chest tightness, shortness of breath, syncope with hypotension, shock and so on. There may be abnormal ECG changes. Admission of oxygen in a timely manner after admission, severe intravenous dexamethasone 5 ~ 10mg, intravenous rehydration to promote discharge, hypotension and shock were increased glucocorticoid dosage and dilatation, intravenous naloxone, etc., all cured. Conclusion Medical workers in the diagnosis and treatment process must pay attention to explain in detail the medication precautions to prevent the occurrence of the disease.