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新华社伦敦3月31日电一个国际团队最新研究发现,一种基因变异可增加黑素瘤发病风险。新发现有助于医学界开发出防治这种恶性皮肤癌的更有效方法。这项研究由英国、荷兰、澳大利亚和美国等国研究人员共同完成,研究结果发表在英国新一期《自然·遗传学》杂志上。研究人员对184名黑素瘤患者进行了基因测序,结果发现,名为POT1的基因如出现变异会显著增加患上黑素瘤的风险。分析显示,该基因变异会抑制与之相应的蛋白质发挥作用,而这种蛋白质的主要功能就是保护染色体,防止其受损。皮肤癌等癌症与染色体受损有密切联系。
Xinhua News Agency, London, March 31 The latest study by an international team found that a genetic mutation can increase the risk of melanoma. New discoveries help the medical community to develop more effective ways to combat this malignant skin cancer. The study by the United Kingdom, the Netherlands, Australia and the United States and other countries to complete the researchers, the findings published in the British issue of “Nature Genetics” magazine. The researchers sequenced 184 melanoma patients and found that a mutation in the gene called POT1 markedly increased the risk of melanoma. Analysis shows that this gene variant will inhibit the corresponding protein play a role, and the main function of this protein is to protect the chromosome to prevent damage. Skin cancer and other cancer and chromosome damage are closely linked.