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甲基吡啶侧链上的氢易于质子化被碱金属所取代,但传统的侧链金属化的方法,其实验操作都比较繁复。前文报道,吡啶与金属钠在乙醚回流中可形成吡啶自由基负离子钠络合物(C_5H_5N~-Na~+),它是一种有效的金属
Hydrogen methyl picoline side of the protonation is easy to replace the alkali metal, but the traditional side-chain metallization method, the experimental operation is more complicated. It was previously reported that pyridine and sodium metal can form pyridine free radical anion sodium complex (C_5H_5N ~ -Na ~ +) in the ether reflux, which is a kind of effective metal