前列腺癌是常见男性泌尿系恶性肿瘤,近年发病率呈明显增长趋势。其机制尚不清楚,大量研究表明CXC趋化因子及其受体在前列腺癌中具有多效性,CXC趋化因子由原发部或远端转移处的肿瘤细胞和基质微环境产生,并参与前列腺癌生长调节、血管生成、侵袭和转移。本文就CXC趋化因子及其受体与前列腺癌的关系作论述,为治疗前列腺癌提供依据。 Prostate cancer is a common male urinary malignancy, the incidence was significantly increased in recent years. The mechanism is unclear. Numerous studies have shown that CXC chemokines and their receptors are pleiotropic in prostate cancer. CXC chemokines are produced by tumor cells and stromal microenvironments at the primary or distant metastasis and are involved Prostate cancer growth regulation, angiogenesis, invasion and metastasis. This article discusses the relationship between CXC chemokines and their receptors and prostate cancer, providing evidence for the treatment of prostate cancer.