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育龄妇女超重和肥胖问题日渐突出,成为全球关注的健康问题。越来越多的研究显示,孕前肥胖和孕期过度增重增加子代神经发育障碍的风险,而目前对于孕前肥胖和孕期过度增重引起儿童神经发育障碍的机制还不是十分明确。新兴的研究表明,母体超重和肥胖引起的全身慢性炎症和胎盘炎症可能介导子代神经发育障碍的发生。本综述主要就孕前肥胖和孕期过度增重引起子代神经发育障碍相关的母体全身炎症和胎盘炎症进行探讨。
The problem of overweight and obesity in women of childbearing age has become increasingly prominent and has become a global health concern. More and more studies show that pre-pregnancy obesity and over-weight during pregnancy increase the risk of neurodevelopmental disorders in offspring. At present, the mechanism of pre-pregnancy obesity and neuropsychiatric disorders caused by excessive pregnancy during pregnancy is not yet clear. Emerging studies have shown that systemic chronic inflammation and placental inflammation caused by maternal overweight and obesity may mediate the occurrence of neurodevelopmental disorders in offspring. This review focuses on maternal systemic inflammation and placental inflammation related to pre-pregnancy obesity and over-weight gain during pregnancy caused by neurodevelopmental disorders in offspring.