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研究了一种同时测定 2 -氨基萘 - 6-磺酰甲胺及其杂质 (2 -氨基萘 ,2 -乙酰氨基萘 - 6-磺酸 ,2 -氨基萘 - 6-磺酸和 2 -乙酰氨基萘 - 6-磺酰甲胺 )含量的高效液相色谱法。采用Hypersil BDS C1 8色谱柱 ,0 .2 %四丁基铵高氯酸盐 (TBAPC) /乙腈 /36%乙酸 (60∶ 38∶2 ,V/V/V)为流动相 ,柱温 30℃ ,在流速为 1 m L/min时 ,上述 5种物质在 2 0 min内实现了基线分离。本方法快速、准确 ,适用于 2 -氨基萘 - 6-磺酰甲胺生产的在线监控以及产品质量监督
A novel method for the simultaneous determination of 2 - aminonaphthalene - 6 - sulfonylmethylamine and its impurities (2 - aminonaphthalene, 2 - acetylaminonaphthalene - 6 - sulfonic acid, 2 - aminonaphthalene - 6 - sulfonic acid and 2 - Aminonaphthalene - 6 - sulfonylmethylamine) content of high performance liquid chromatography. The mobile phase consisted of Hypersil BDS C1 8 column, 0.2% tetrabutylammonium perchlorate (TBAPC) / acetonitrile / 36% acetic acid (60:38:2, V / V / V) , At a flow rate of 1 m L / min, the above five substances achieved baseline separation within 20 min. The method is rapid and accurate and is suitable for on-line monitoring of 2-aminonaphthalene-6-sulfonylmethane production and product quality supervision