关于胸腔内注射米诺环素致胸膜纤维化的长期作用不明,本文就此进行了研究。 取雄性新西兰白兔25只,以氯噻酮35mg/kg和甲苯噻嗪5mg/kg麻醉后,经25号针于右侧胸腔注射溶于2ml灭菌生理盐水的米诺环素10mg/kg。于术后15天,1、2、4、6个月分组处死,每组5只。进行肉眼和显微镜观察,纤维化和炎症按程度分为0～5级。 The long-term effect of intrapleural minocycline-induced pleural fibrosis is unknown, and this article has been studied. Twenty-five male New Zealand white rabbits were anesthetized with chlorthalidone 35 mg / kg and xylazine 5 mg / kg, and minocycline 10 mg / kg dissolved in 2 ml sterilized physiological saline was injected through the 25 th needle on the right side of the chest. At 15 days after operation, the animals were sacrificed in 1, 2, 4 and 6 months after operation. For macroscopic and microscopic observation, fibrosis and inflammation were divided into 0 ~ 5 according to the degree.