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目的:研究中草药补气与镇痛二类药合用的镇痛作用。方法:用具有较好镇痛作用的中草药制成胶囊剂,作为对照组,再在对照组处方的基础上加入具有较好补气作用的中草药,工艺与对照组相同,制成胶囊剂,作为实验组,用二组的胶囊内容物配成所需浓度的药液给小白鼠分别灌胃,然后用热板法及甩尾法进行测定其痛阈值,实验结果与生理盐水组以及对照组与实验组作比较。结果:实验组、对照组在30min、60min、90min内与生理盐水组比较,差异均有显著性意义(P<0.05),实验组与对照组比较,差异均有显著性意义(P<0.05)。结论:在中草药镇痛类药味及剂量相同的条件下,加入具有补气作用的中草药能增强中草药制剂的镇痛疗效。
Objective: To study the analgesic effect of Chinese herbal medicine supplementing qi and analgesic drugs. Methods: Capsules were made from Chinese herbal medicines with good analgesic effect as a control group. Chinese herbal medicines with good qi effect were added on the basis of prescriptions of the control group. The same process as the control group was used to make capsules. In the experimental group, mice were intragastrically administered with the required concentration of the drug solution in the capsule contents of the two groups, and then the pain threshold was measured by the hot plate method and the tail-flicking method. The experimental results were similar to that of the saline group and the control group. Experimental group for comparison. Results: There was significant difference between the experimental group and the control group compared with the saline group within 30min, 60min, and 90min (P<0.05). The difference between the experimental group and the control group was significant (P<0.05). . Conclusion: Under the condition of the same herbal medicine and analgesic dosage, the addition of herbal medicine with qi effect can enhance the analgesic effect of Chinese herbal medicine.