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复制沙土鼠实验性脑缺血再灌流模型，测定了在缺血及再灌流不同阶段血清及脑组织中超氧化物歧化酶（ＳＯＤ）的活性和脂质过氧化反应最终产物（ＭＤＡ）的含量变化，结果发现单纯缺血组与再灌流各组脑组织ＭＤＡ的含量均高于正常对照组，且再灌流１ｈ、６ｈ组的ＭＤＡ含量明显高于单纯缺血组（Ｐ＜０．０５），并有随再灌时间延长不断升高的趋势，但三个再灌流组之间比较无明显差异。单纯缺血组与再灌流各组比较脑组织ＳＯＤ的活性均较正常对照组降低，以再灌１ｈ、６ｈ最为明显，与单纯缺血组比较Ｐ＜０．０５。实验各组与正常对照组比较血浆ＳＯＤ的活性无显著差异。表明单纯缺血和再灌流后均发生了脂质过氧化反应，并认为自由基引起的损伤，在缺血后再灌流中比单纯缺血更为严重。
The model of gerbil was established by intracerebral hemorrhagic shock model. The activities of superoxide dismutase (SOD) and the content of lipid peroxidation (MDA) in serum and brain tissue were determined during different stages of ischemia and reperfusion. The results showed that the content of MDA in brain tissue of ischemia group and reperfusion group were higher than that of normal control group, and the content of MDA in reperfusion group was significantly higher than that in ischemia group (P <0.05) There was a trend of increasing with the reperfusion time, but there was no significant difference between the three reperfusion groups. Compared with the control group, the activities of SOD in brain tissue in reperfusion group and ischemia group were lower than those in normal control group, especially in reperfusion for 1h and 6h (P <0.05). There was no significant difference in plasma SOD activity between experimental groups and normal control group. It showed that both lipid peroxidation occurred after ischemia and reperfusion, and the damage caused by free radicals was considered more serious than ischemia after reperfusion.