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Chernoff/Kavlock试验是近年来发展的发育毒性体内筛选试验。本文利用此试验筛选和预测环磷酰胺(CP)、维生素A(VA)及珊瑚提取液的发育毒性。昆明种小鼠,于孕第6～14日隔日一次染毒。CP10mg/kg/次腹腔注射和VA45mg/kg/次灌胃可引起母鼠体重增长降低、仔鼠出生第1日
The Chernoff / Kavlock test is a developmentally toxic in vivo screening test developed in recent years. In this study, we used this test to screen and predict the developmental toxicity of cyclophosphamide (CP), vitamin A (VA) and coral extracts. Kunming mice, pregnant in the first 6 to 14 every other day of exposure. CP10mg / kg / intraperitoneal injection and VA45mg / kg / dose gavage can cause decreased weight gain in maternal rats born on the first day