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头孢三嗪(ceftriaxone)常用于治疗由革兰氏阴性菌引起的婴儿和儿童脓毒症或脑膜炎。有报道接受头孢三嗪治疗的患儿可发生腹泻。一组前瞻性对比试验,27例接受头孢三嗪治疗者中的16例(59%)和23例接受氨苄青霉素和氯霉素联合治疗者中的5例(22%)发生腹泻。本研究的50例患儿(年龄3月至12岁), 其中细菌性脑膜炎占72%、病毒性脑膜炎占8%、窦炎占8%、发热占4%、眶周蜂窝织炎占2%、细菌性肺炎占2%、病毒性疾病占2%和哮喘占2%。患儿均接受头孢三嗪500mg/kg,静脉注射20分钟,每12小时一次,连续3-14天。结果发现50例患儿中有17例(34%)发生腹泻(每日大便≥4次)。腹泻发生在用药2-14(8.7±3.2)次后,持续2-8(3.1±1.7)天。17例腹泻者,腹泻前每日大
Ceftriaxone is commonly used to treat sepsis or meningitis in infants and children caused by Gram-negative bacteria. Diarrhea can occur in children treated with ceftriaxone. A prospective controlled trial of diarrhea occurred in 16 of 27 (59%) patients receiving ceftriaxime and 5 (22%) of 23 patients receiving ampicillin and chloramphenicol. Fifty children (aged from March to 12 years) of this study included bacterial meningitis 72%, viral meningitis 8%, sinusitis 8%, fever 4%, orbital cellulitis 2%, bacterial pneumonia 2%, viral disease 2% and asthma 2%. Children received ceftriaxone 500mg / kg, intravenous injection of 20 minutes, once every 12 hours for 3-14 days. It was found that diarrhea occurred in 17 (34%) of 50 children (> 4 stools per day). Diarrhea occurred 2-8 (3.1 ± 1.7) days after 2-14 (8.7 ± 3.2) dosing sessions. 17 cases of diarrhea, large daily before diarrhea