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目的:研究乳腺非霍奇金淋巴瘤(NHL)的组织形态特点及免疫表型.方法:对17例乳腺NHL作形态学分析,其中11例进行了免疫学标记.结果:13例为原发性,4例为继发性.8例(47.06%)见“淋巴上皮病变”,13例(76.47%)见肿瘤浸润脉管,4例(23.53%)伴有“淋巴细胞性乳腺病”,3例(17.65%)见局部瘤细胞呈靶环样排列.免疫组化示16例(94.12%)为B细胞NHL,其中2例(12.50%)KP1阳性,1例(6.25%)UCHL-1阳性.结论:(1)大多数乳腺原发性NHL为MALT型淋巴瘤;(2)淋巴细胞性乳腺病可能是一些乳腺NHL的前驱病变;(3)少数B细胞NHL能与KP1或UCHL-1发生交叉反应.
Objective: To study the histomorphology and immunophenotype of breast non-Hodgkin’s lymphoma (NHL) .Methods: Seventeen breast NHLs were morphologically analyzed and 11 of them were immunologically labeled.Results: (4 cases were secondary), 8 cases (47.06%) were found in “lymphoid epithelial lesions”, 13 cases (76.47%) were found to have tumor infiltration vessels, 4 cases (23.53% In 3 cases (17.65%), local tumor cells showed target ring-like arrangement. Immunohistochemistry revealed 16 cases (94.12%) of B cell NHL, 2 cases (12.50%) KP1 positive and 1 case (6.25%) UCHL-1 (2) Lymphocytic mammary disease may be a precursor of some breast NHLs; (3) A few B-cell NHLs may be associated with KP1 or UCHL- 1 cross-reaction occurred.