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复方氯唑沙宗片是由氯唑沙宗和对乙酰氨基酚组成的中枢骨骼肌松弛剂,已被列入美国21版药典。氯唑沙宗和对乙酰氨基酚有镇痛协同作用。临床验证表明:复方氯唑沙宗片疗效优于氯唑沙宗片。 1 药理作用研究 1.1 肌肉松弛作用:以小鼠攀网法肌松作用比较,复方氯唑沙宗片与氯唑沙宗片都具有肌肉松弛作用,且呈剂量依赖性,ED_(50)复方氯唑沙宗片为195.72±37.83mg/kg,氯唑沙宗片为187.50±34.40mg/kg,若将复方制剂的ED_(50)以其中所含氯唑沙宗的剂量计算,其ED_(50)仅88.97mg/kg,低于单方应用氯唑沙宗。
Compound chlorzoxazone tablets by the chlorzoxazone and acetaminophen composed of central skeletal muscle relaxants, has been included in the United States 21 Pharmacopoeia. Chlorzoxazone and acetaminophen have analgesic synergy. Clinical validation shows that the efficacy of compound chlorzoxazone is better than that of chlorzoxazone. 1 Pharmacological studies 1.1 Muscle relaxation: Compared with the muscle climbing effect of the mouse climbing net method, both the compound chlorzoxazone tablets and the chlorzoxazone tablets have a muscle relaxation effect and in a dose-dependent manner. ED 50 chlorine compound The azole sand tablets were 195.72 ± 37.83mg / kg and the chlorzoxazone tablets were 187.50 ± 34.40mg / kg. If ED_ (50) of the compound prescription was calculated by the dosage of chlorzoxazone, the ED_ (50) ) Was only 88.97 mg / kg, lower than unilateral clozaczone.