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【目的】观察学龄期肥胖与体重正常儿童血清25羟维生素D[25(OH)D]水平及其与儿童肥胖程度及糖脂代谢的关系。【方法】按照《中国0～18岁儿童青少年体块指数的生长曲线》标准,从学龄期儿童中筛选出超重和肥胖儿童作为肥胖组,并设置同年龄、体重正常儿童为对照组。采用ELSIA测定血清25羟维生素D[25(OH)D]、甲状旁腺素(parathyroid hormone,PTH),全自动生化分析仪测定血生化指标。【结果】肥胖儿童59人(男童45人,女童14人),平均年龄(9.58±2.39)岁,BMI为25.14±4.02;对照组35人(男童23人,女童12人),平均年龄(8.92±1.56)岁,BMI为15.56±1.51。肥胖组儿童血清25(OH)D(45.40±11.86)nmol/L明显低于对照组儿童(59.56±16.08)nmol/L,差异有高度统计学意义(P<0.001),骨密度低于正常组儿童(P<0.001);血清25(OH)D浓度与BMI SDS、腰围、腰臀比及血甘油三脂呈显著负相关(P<0.05);25(OH)D低于50nmol的肥胖儿童的甘油三脂水平[(2.08±0.26)mmol/L]明显高于25(OH)D大于50nmol的肥胖儿童[(1.41±0.14)mmol/L]。【结论】肥胖儿童血清25(OH)D浓度明显低于体重正常儿童,血清25(OH)D浓度与儿童BMI SDS、腰围、甘油三脂呈负相关提示维生素D缺乏可能是儿童中心性肥胖和代谢综合症的危险因素。
【Objective】 To observe the serum 25-hydroxyvitamin D [25 (OH) D] levels in school-age obese and normal weight children and their relationship with obesity and glucose and lipid metabolism in children. 【Methods】 According to the “growth curve of body mass index of children and adolescents aged 0 ~ 18 years in China”, overweight and obese children were screened from the school-age children as the obese group and the same age and normal weight children as the control group. Serum 25-hydroxyvitamin D [25 (OH) D], parathyroid hormone (PTH) and automatic biochemical analyzer were used to determine blood biochemical parameters by ELSIA. 【Results】 There were 59 obese children (45 boys and 14 girls) with an average age of (9.58 ± 2.39) years and a mean BMI of 25.14 ± 4.02. In the control group, 35 (23 boys and 12 girls) (8.92 ± 1.56) years old, BMI 15.56 ± 1.51. The serum 25 (OH) D (45.40 ± 11.86) nmol / L in obese group was significantly lower than that in control group (59.56 ± 16.08) nmol / L, the difference was statistically significant Children (P <0.001). Serum 25 (OH) D concentration was negatively correlated with BMI SDS, waist circumference, waist-hip ratio and triglyceride (P < The level of triglyceride [(2.08 ± 0.26) mmol / L] was significantly higher in obese children [(1.41 ± 0.14) mmol / L] with 25 (OH) D greater than 50 nmol. 【Conclusion】 The serum 25 (OH) D concentration in obese children was significantly lower than that of normal weight children. The negative correlation between serum 25 (OH) D concentration and children’s BMI SDS, waist circumference and triglyceride suggested that vitamin D deficiency may be central obesity and Risk factors for metabolic syndrome.