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临床流行病学已经证实高密度脂蛋白胆固醇水平与心血管意外的风险呈负相关。高密度脂蛋白通过促进胆固醇酯的逆向转运,减少胆固醇在外周组织和血管的沉积;抑制低密度脂蛋白的物理和化学修饰从而减少泡沫细胞的形成;降低黏附分子和巨噬细胞趋化蛋白的活性从而抑制慢性炎症;减轻内皮功能的紊乱而发挥心血管的保护作用已经成为共识。然而,随着多项以升高高密度脂蛋白水平,逆转动脉硬化进程为目的的研究结果的公布,对高密度脂蛋白有了新的评价,认为高密度脂蛋白的功能比水平更为重要,高密度脂蛋白胆固醇与心血管疾病的关系还有待探索。
Clinical epidemiology has confirmed a negative correlation between HDL cholesterol levels and the risk of cardiovascular accidents. High-density lipoproteins reduce the deposition of cholesterol in peripheral tissues and blood vessels by promoting the reverse transport of cholesteryl esters; inhibit the physical and chemical modification of low-density lipoproteins and thereby reduce the formation of foam cells; decrease the expression of adhesion molecules and macrophage chemotactic proteins Activity and thus inhibit chronic inflammation; reduce endothelial dysfunction and play a cardiovascular protective effect has become the consensus. However, with the publication of several studies aimed at reversing the progression of atherosclerosis with a number of high-density lipoprotein levels, high-density lipoproteins have been newly evaluated and considered to be more important than high-density lipoproteins , The relationship between high-density lipoprotein cholesterol and cardiovascular disease remains to be explored.