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初步比较了大花罗布麻[APoacynum hendersonii(Hook.f.)Woodsan]叶浸膏乙醇提取物(P.H.-1)与罗布麻(APpocynttm venetum L.)叶浸膏的降血压作用,大鼠po或ip及猫ivP.H.-1后降压效果均优于罗布麻浸膏,P.H.-1对肾性高血压大鼠也呈现明显而持久的降压作用。此外,P.H.-1尚有降血脂,改善心脏功能、抑制血小板聚集及延缓衰老等作用。实验结果提示:P.H.-1可能为一种多功能的降压药,尤适宜于老年高血压患者。
A preliminary comparison of the antihypertensive effect of Apocynum hendersonii (Hook.f.) Woodsan] leaf extract ethanol extract (PH-1) and Apocynttm venetum L. leaf extracts, rat po or Both ip and cat iv P.H.-1 had better antihypertensive effect than apocynum extract. PH-1 also showed significant and sustained antihypertensive effect on renal hypertensive rats. In addition, P.H.-1 has hypolipidemic effects, improves heart function, inhibits platelet aggregation, and delays aging. The experimental results suggest that P.H.-1 may be a multifunctional antihypertensive drug, especially suitable for elderly hypertensive patients.