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目的 探讨内耳色素与爆震性听损伤的关系。方法 选用豚鼠 48只 ,分为 :白化豚鼠爆震组 ,杂色豚鼠爆震组 ,正常对照组。爆震前及爆震后 6小时、1、2、7、14、2 1天测定A、B组豚鼠ABR阈值。处死豚鼠做耳蜗铺片、耳蜗树脂包埋半薄切片、耳蜗扫描电镜制样 ,观察耳蜗内色素及耳蜗损伤情况。结果 光镜下杂色豚鼠可见耳蜗内色素颗粒 ,而白化豚鼠未见。爆震后白化豚鼠听力损伤比杂色豚鼠严重 ,其听力恢复亦较杂色豚鼠慢。爆震后白化豚鼠的永久性反应阈偏移值大于杂色豚鼠的永久性反应阈偏移值。光镜和扫描电镜显示爆震后白化豚鼠耳蜗病损的范围大于杂色豚鼠 ,程度亦较重。结论 内耳血管纹色素颗粒与爆震性内耳损伤有关 ,其机理可能为色素颗粒参与调节爆震后内淋巴液中离子浓度的平衡及参与清除爆震后耳蜗产生的氧自由基
Objective To investigate the relationship between pigmentation and detonation hearing loss in the inner ear. Methods 48 guinea pigs were selected and divided into: albino guinea pig detonation group, variegated guinea pig detonation group and normal control group. The ABR thresholds of guinea pigs in group A and group B were measured on day 1, day 7, day 7 and day 6 after detonation and 6 hours after detonation. Guinea pigs were sacrificed to make cochlear implants, cochlear resin embedded semi-thin slices, cochlear scanning electron microscopy samples to observe the cochlear pigment and cochlear damage. Results light microscope variegated guinea pig cochlear pigment particles can be seen, while no albino guinea pigs. After detonation, albino guinea pigs had more severe hearing impairment than variegated guinea pigs, and their hearing recovery was slower than that of variegated guinea pigs. The permanent threshold removals of albino guinea pigs after detonation were greater than those of variegated guinea pigs. Light and scanning electron microscopy showed that the extent of cochlear lesions in guinea pigs after detonation was greater than that in variegated guinea pigs, with a greater degree of severity. Conclusion Pigment of the inner ear vascular pigment is associated with detonation of the inner ear. The mechanism may be that the pigment granules are involved in regulating the balance of ion concentration in the endolymph after detonation and are involved in the clearance of the oxygen radicals produced by the cochlea after detonation