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目的 探讨胎盘多肽 (PPs)对小鼠肿瘤细胞体内、外生长的影响。方法 染料排斥试验及肿瘤细胞体内种植实验。结果 PPs在体外对肿瘤细胞无明显的直接杀伤作用 (P >0 0 5 ) ,但体内肿瘤种植实验中给药组H2 2 腹水瘤小鼠生命延长率为 70 % ,S180 实体瘤生长抑制率为 6 5 % ,与对照组相比实验组荷瘤小鼠生存时间有显著差异 (P <0 0 1 )且肿瘤的形成也有明显的抑制作用 (P <0 0 1 )。结论 PPs在体内有明显的抑瘤作用
Objective To investigate the effect of placental polypeptides (PPs) on the growth of mouse tumor cells in vivo and in vitro. Methods Dye exclusion test and tumor cell in vivo implantation experiments. Results There was no obvious direct killing effect of PPs on tumor cells in vitro (P > 0.05), but the survival rate of H2 2 ascites tumor mice in the in vivo tumor implantation experiment was 70%, and the growth inhibition rate of S180 solid tumor was Compared with the control group, the survival time of the tumor-bearing mice in the experimental group was significantly different from that in the control group (P < 0 01), and tumor formation was also significantly inhibited (P <0 01). Conclusion PPs have obvious anti-tumor effect in vivo