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WT1基因位于人类染色体11p13,分子量约50kb,编码产物为转录调节因子,与Wilms瘤的形成密切相关,它的突变与AML的未成熟表型有关~([1])。笔者就WT1在造血系统肿瘤中的表达、表达调控、靶基因及临床应用价值的研究进行综述。现报告如下。1 WT1基因与造血系统肿瘤1.1 WT1在白血病中的表达及其意义WT1在急性髓系白血病(AML)中异常过度表
The WT1 gene is located on human chromosome 11p13 and has a molecular weight of about 50 kb. The coding product is a transcriptional regulator that is closely related to Wilms’ tumor formation. Its mutation is related to the immature phenotype of AML (1). The author reviews the expression of WT1 in hematopoietic tumors, the regulation of expression, the target genes and the clinical value. The report is as follows. 1 WT1 gene and hematopoietic tumors 1.1 WT1 expression in leukemia and its significance WT1 in acute myeloid leukemia (AML) abnormal hyperm table