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目的：探讨癌肉瘤组织学本质，为临床选择治疗方案提供理论根据。方法：应用肥免疫组化方法，对11例癌肉瘤分别作了CK，EMA及Vimentin标记．部分病例作了S－100，α1－ACT，Desmin及Mvoglobin标记。结果：结合光镜HE切片及免疫标记进行分析，其中8例肿瘤中所谓间叶样成分，同时对CK或EMA呈阳性表达，且癌与肉瘤样区有移行，诊断为肉瘤化癌；另3例癌与肉瘤间无移行关系，且两种成分别仅对CK，EMA及Vimentin表达，诊断为癌肉瘤。结论：本文结果支持全能干细胞恶变后双向分化形成此类肿瘤的全能干细胞学说，这类肿瘤多数的本质是癌伴肉瘤化。
Objective: To investigate the histological nature of carcinosarcoma and provide theoretical basis for the clinical choice of treatment plan. Methods: Apply immunohistochemical method to make CK, EMA and Vimentin markers in 11 cases of carcinosarcoma. Some cases were labeled with S-100, α1-ACT, Desmin and Mvoglobin. RESULTS: Combined with HE microscopy and immunolabeling analysis, 8 of the tumors were characterized as so-called mesenchymal components, and were positive for CK or EMA expression, and there was a transition between carcinoma and sarcomatoid area. The diagnosis was sarcoma cancer; 3 There was no transitional relationship between cases of carcinoma and sarcoma, and the two types were only expressed in CK, EMA and Vimentin, and they were diagnosed as carcinosarcoma. Conclusion: The results of this study support the theory that totipotent stem cells have two-way differentiation to form such tumors after malignant transformation. The majority of these types of tumors are cancerous and sarcomatous.