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目的通过研究丙硫氧嘧啶对妊娠合并甲状腺功能亢进症(甲亢)的疗效及对妊娠结局的影响,为临床治疗提供依据。方法 200例妊娠合并甲亢患者,随机分成观察组和对照组,各100例。观察组患者采用丙硫氧嘧啶进行治疗,对照组患者在确诊之后没有及时的对甲状腺进行定期复查就自行停药或直接拒绝服用丙硫氧嘧啶进行治疗。对比两组患者的血清促甲状腺激素(TSH)、血清游离甲状腺素(FT_4)、血清游离三碘甲状腺原氨酸(FT_3)、总甲状腺素(TT_4)、总三碘甲状腺原氨酸(TT_3)激素水平以及两组患者的妊娠结局。结果治疗后,观察组患者的TSH、FT_4、FT_3、TT_4、TT_3激素水平均优于对照组,差异均具有统计学意义(t=62.947、30.969、33.373、16.899、8.113,P<0.05)。观察组不良妊娠结局发生率2.0%低于对照组34.0%,差异具有统计学意义(χ~2=34.688,P<0.05)。结论采用丙硫氧嘧啶对妊娠合并甲亢患者进行治疗的效果较好,最终患者的再次妊娠情况也较好,值得临床推广使用。
Objective To study the efficacy of propylthiouracil on pregnancy complicated with hyperthyroidism (Hyperthyroidism) and its effect on pregnancy outcome, so as to provide the basis for clinical treatment. Methods 200 cases of pregnancy with hyperthyroidism were randomly divided into observation group and control group, each 100 cases. Patients in the observation group were treated with propylthiouracil, and patients in the control group were discontinued on their own or did not take propylthiouracil directly after the diagnosis was performed without regular review of the thyroid. The levels of serum TSH, FT_4, FT_3, TT_4 and TT_3 were compared between the two groups. The serum thyroid hormone (TSH), total thyroxine Hormone levels and pregnancy outcomes in both groups. Results After treatment, the levels of TSH, FT_4, FT_3, TT_4 and TT_3 in the observation group were significantly better than those in the control group (t = 62.947, 30.969, 33.373, 16.899, 8.113, P <0.05). The incidence of adverse pregnancy outcomes in the observation group was 2.0% lower than that in the control group (34.0%), the difference was statistically significant (χ ~ 2 = 34.688, P <0.05). Conclusion Propylthiouracil treatment of hyperthyroidism in pregnancy patients with better results in the final pregnancy of patients is also better, it is worth promoting the use of the clinic.