【摘 要】
：
Tagetones A(1) and B(2), two new monocyclic diterpenoids were isolated from the n-hexane fraction of fresh flowers of Tagetes minuta L.(Asteraceae). Their struc
【机 构】
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Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University,Dep
【出 处】
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Chinese Journal of Natural Medicines
论文部分内容阅读
Tagetones A(1) and B(2), two new monocyclic diterpenoids were isolated from the n-hexane fraction of fresh flowers of Tagetes minuta L.(Asteraceae). Their structures were established by multiple spectroscopic methods(IR, HR-ESI-MS, and 1D-, and 2D-NMR), in addition to comparison with literature data. Compound 1 showed cytotoxic activity towards MCF7 and A549 cancer cells with IC_(50) values being 4.68 and 4.24 μmol·L~(-1), respectively, compared to doxorubicin(IC_(50) 0.13 and 1.12 μmol·L~(-1), respectively). Compound 2 also exhibited significant activity against HCT116 cancer cells(IC_(50), 6.30 μmol·L~(-1)).
Their structures were established by multiple spectroscopic methods (IR, HR-ESI-MS). Tagetones A (1) and B MS, and 1D-, and 2D-NMR), in addition to comparison with literature data. Compound 1 showed cytotoxic activity toward MCF7 and A549 cancer cells with IC 50 values being 4.68 and 4.24 μmol·L -1, (IC_ (50) 0.13 and 1.12 μmol·L -1, respectively). Compound 2 also showed significant activity against HCT116 cancer cells (IC 50, 6.30 μmol·L -1) ).
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