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近年来,随着联合化疗和支持疗法的进步,使得初治成人急性白血病的完全缓解率(CR)显著提高.但仍有少部分患者化疗效果差.国外应用去甲氧柔红霉素(Zavedos,Z)治疗难治性及复发性病例,均获得较满意的CR.本文用去申氧柔红霉素与阿糖胞苷(Ara—C)联合治疗难治性急性白血病5例,报告如下.1 材料与方法1.1 病例选择 5例均为住院患者,男2例,女3例;年龄30～64岁(中位数42.6岁).经临床、血象、骨髓象及细胞组织化学染色等检查确诊,按1986年国内白血病分类分型讨论会制订的标准,亚型分布为:急淋1例(L_2),急非淋4例(M_2a1例,M_53例).1例急淋患者用CODP(环磷酰胺,长春新碱,柔红霉素.强的松)方案4个疗程,4例急非淋用D(H)A方案均两
In recent years, with the advancement of combined chemotherapy and supportive therapy, the complete remission rate (CR) of newly diagnosed adult acute leukemia has increased significantly. However, there are still a small number of patients with poor chemotherapy effects. Foreign application to idarubicin (Zavedos) , Z) Treatment of refractory and relapsed cases, all received satisfactory CR. This article used rosalcin and cytarabine (Ara-C) in the treatment of refractory acute leukemia in 5 cases, the report is as follows: .1 Materials and Methods 1.1 Case selection All 5 patients were hospitalized patients, 2 males and 3 females; aged 30 to 64 years (median 42.6 years). Clinical, blood, bone marrow, and histochemical staining The diagnosis was based on the criteria set by the domestic leukemia classification and classification conference in 1986. The distribution of subtypes was: acute case of 1 case (L_2), acute non-lymphination in 4 cases (M_2a1 case, M_53 case). One case of acute leukemia patient was treated with CODP ( Cyclophosphamide, vincristine, daunorubicin, prednisone) 4 courses of therapy, 4 cases of acute non-leaching D(H)A regimen