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目的:研究结肠宁颗粒抗结肠炎的作用。方法:选用苦寒泻下的番泻叶和化学刺激物冰乙酸复制大鼠脾虚型溃疡性结肠炎模型,观察结肠宁颗粒抗溃疡性结肠炎的作用;选用大黄致脾虚型小鼠模型,观察结肠宁颗粒的益肠补脾,涩肠止泻的作用。结果:结肠宁颗粒能显著减轻脾虚型溃疡性结肠炎模型大鼠的结肠大体形态损伤、组织学损伤及体重减轻程度;延长大黄致脾虚型小鼠的排便时间、减少2 h内排黑便点数,减少脾虚模型小鼠体重减轻的程度。结论:结肠宁颗粒具有抗大鼠脾虚型溃疡性结肠炎作用,同时能改善脾虚型小鼠的症状,对结肠炎有一定的治疗作用。
Objective: To study the effect of colonic granules against colitis. Methods: The rat model of ulcerative spleen-deficiency ulcer colitis was induced by senna of senna of bitter cold and chemical irritation glacial acetic acid, and the effect of “Zhuganning granule” on ulcerative colitis was observed. The mouse model of rhubarb-induced spleen deficiency was selected and the colon Ning particles of the intestine spleen, astringent intestinal diarrhea effect. Results: Granule can significantly reduce the colonic mucosal damage, histological damage and weight loss in rats with spleen-deficiency ulcerative colitis model; prolong the defecation time of rhubarb-induced spleen deficiency mice, , Reducing the extent of weight loss in spleen-deficient mice. Conclusion: Colon Granule has anti-spleen-type ulcerative colitis, can improve the symptoms of spleen-deficiency mice and has a certain therapeutic effect on colitis.