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ＢＣＲ ＡＢＬ酪氨酸激酶是Ｐｈ染色体嵌合基因的产物 ,此酶几乎见于所有的慢性粒细胞白血病 (ＣＭＬ)病例 ,且贯穿于疾病的始终。此外 ,约 2 0 %的急性淋巴细胞白血病 (ＡＬＬ)病例也可发现ＢＣＲ ＡＢＬ酪氨酸激酶。ＳＴＩ571是一种有效的、特异性ＢＣＲ ＡＢＬ酪氨酸激酶抑?
The BCR ABL Tyrosine Kinase is the product of the Ph Chromosome chimeric gene found in almost all cases of chronic myeloid leukemia (CML) throughout the disease. In addition, about 20% of acute lymphoblastic leukemia (ALL) cases can also be found in BCR ABL tyrosine kinase. Is STI571 a potent, specific BCR ABL tyrosine kinase inhibitor?