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目的研究急性缺血性卒中早期神经功能恶化与感染及颈动脉斑块性质的关系。方法急性缺血性卒中患者558例,将其中107例早期神经功能恶化患者作为研究组,451例早期神经功能无恶化患者作为对照组,记录两组患者的感染率、不稳定斑块发生率、C反应蛋白(CRP)水平、美国国立卫生院神经功能缺损评分(NIHSS)情况。结果研究组CRP水平、NIHSS评分及感染率、不稳定斑块发生率均明显高于对照组(P<0.05)。结论急性缺血性卒中早期神经功能发生恶化是由患者的感染程度、NIHSS评分情况、颈动脉不稳定斑块情况以及CRP水平等各种相关因素共同影响产生的结果。
Objective To study the relationship between early deterioration of neurological function and infection and carotid plaque in acute ischemic stroke. Methods A total of 558 patients with acute ischemic stroke were enrolled in this study. One hundred and seventy patients with early neurological deterioration were included in the study. 451 patients with no early neurological deterioration were selected as the control group. The infection rate, the incidence of unstable plaque, C-reactive protein (CRP) levels, National Institutes of Health neurological deficit score (NIHSS). Results The CRP level, NIHSS score and infection rate, and the incidence of unstable plaque in the study group were significantly higher than those in the control group (P <0.05). Conclusion The early deterioration of neurological function in patients with acute ischemic stroke is caused by various factors such as the degree of infection, NIHSS score, unstable carotid plaque and CRP level.