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非蛋白巯基(NPSH)的抑制剂马来酸二乙酯(DEM)与放射增敏剂MISO合并用药对C3H/He小鼠乳瘤的辐射增敏作用超过单独用MISO的任何剂量,并且二者的差别在小剂量MISO时特别显著。合并给MISO 100mg/kg,DEM 760mg/kg,增敏率为2.06;而单独给MISO 100mg/kg时,增敏率ER为1.44。肿瘤细胞内NPSH的含量影响细胞的增敏。肿瘤细胞内NPSH不受MISO的影响,而DEM显著降低肿瘤的NPSH含量,因此提出肿瘤细胞内的NPSH与亲电性放射增放剂之间存在着竞争。将C3H/He小鼠的自发瘤取出捣碎作成悬液,皮
Non-peptone thiol (NPSH) inhibitor, diethyl maleate (DEM), combined with radiosensitizer MISO, has a radiosensitization effect on C3H/He mouse breast tumors over any dose of MISO alone, and both The difference is particularly significant at low doses of MISO. When combined with MISO 100 mg/kg, DEM 760 mg/kg, the sensitization rate was 2.06; and when MISO 100 mg/kg alone was used, the sensitization rate ER was 1.44. The content of NPSH in tumor cells affects the sensitization of cells. NPSH in tumor cells is not affected by MISO, but DEM significantly reduces the NPSH content of tumors. Therefore, there is competition between NPSH and electrophilic radioactivators in tumor cells. The spontaneous tumors of C3H/He mice were smashed and made into a suspension.