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照射后的造血改变首先取决于造血细胞自身的损伤。但有根据认为,照射能引起作用于造血器官建造特殊环境组织的改变。负责造血微环境的不是造血细胞,而是基质组织,其中包括造血器官基质成纤维细胞。本文报道了一种基质细胞即成集落性基质祖细胞(CUF-f)辐射敏感性的研究结果。实验用体外单层培养法,借此可定最测定CFU-f在骨髓和脾脏中的含量。前曾报道,原发性淋巴肉芽肿病病人骨髓CFU-f比肺结核病人的有较高辐射耐受性。穿刺淋巴肉芽肿病人胸骨或髂骨嵴取骨髓。脾脏小块取自这种病人(7例)切脾时。打碎脾脏断片,
Hematopoietic changes after irradiation depend primarily on the injury of the hematopoietic cells themselves. However, it is argued that exposure can cause changes in the organization of specific environmental tissues that act on hematopoietic organs. It is not hematopoietic cells responsible for the hematopoietic microenvironment, but stromal tissue, including hematopoietic-derived stromal fibroblasts. This paper reports the results of a study on the radiosensitivity of stromal cells, ie, mesenchymal stromal progenitor cells (CUF-f). Experiment with in vitro monolayer culture method, which can be the most determinable CFU-f content in the bone marrow and spleen. It was previously reported that CFU-f in patients with primary lymphocytic granulomatosis had a higher radiation tolerance than tuberculosis patients. Puncture of patients with lymphogranuloma sternal or iliac crest bone marrow. Spleen pieces taken from this patient (7 cases) at the time of splenectomy. Broken spleen fragments,