目的 探讨结直肠隆性病变接受内镜下黏膜剥离术（ESD）围手术期的护理方法以及护理效果。方法 选取2019年1月至2020年12月于我院接受ESD治疗的120例结直肠隆性病变患者作为研究对象，应用随机数字表法，分为观察组（综合护理干预）和对照组（常规护理），各60例，比较两组患者的护理效果。结果 观察组患者的护理满意度（96.67%vs.83.33%，χ^2=5.926）高于对照组（P＜0.05），观察组患者的术后并发症发生率（3.33%vs.13.33%，χ^2=3.927）、焦虑自评量表（SAS）评分[“,”Objective To explore the perioperative nursing methods and nursing effects of endoscopic mucosal dissection (ESD) for colorectal carinal lesions. Methods All 120 patients with colorectal carinal lesions treated by ESD in our hospital from January 2019 to December 2020 were selected as the research object. They were randomly divided into observation group (comprehensive nursing intervention) and control group (routine nursing) with 60 cases in each group. The nursing effects of the two groups were compared. Results Nursing satisfaction in the observation group (96.67% vs. 83.33%， χ^2=5.926)was higher than in the control group (P＜0.05)，the incidence of postoperative complications in the observation group was 3.33% vs. 13.33%， χ^2=3.927)， self rating Anxiety Scale (SAS) score [(37.54±3.92) score vs. (45.81±4.37) score， t=10.912]， the Depression Self-Evaluation Scale (SDS) score [(38.51±4.08)score vs. (46.73±5.91)score， t=8.866]， pain VAS score [(1.84±0.72) score vs. (2.77±0.85) score， t=6.467] were lower than those in the control group(P＜0.05). The anal recovery and exhaust time in the observation group [(49.37±5.82)hours vs. (62.04±6.31)hours， t=11.433]， the ambulation time[(25.43±3.28)hours vs. (36.08±4.46)days， t=14.901] and the hospitalization time [(5.43±1.75) days vs. (7.02±2.04)days， t=4.582] were shorter than those in the control group (P＜0.05). Conclusion ESD is a method for the treatment of colorectal carinal lesions. Nursing intervention during surgical treatment can effectively reduce the operation risk and have a positive impact on the rapid and good recovery of patients after operation.