目的 :观察丹参注射液对大鼠酒精性肝损伤病理组织学的影响 ,为临床治疗酒精性肝损伤提供实验依据。方法 :选取大鼠采用白酒灌胃造模 ;以正常饮食、饮水组为对照 ;以丹参注射液治疗后 ,于各组大鼠肝脏取材 ,常规HE染色、光镜观察。结果 :模型组肝正常组织结构消失 ,小叶界限不清 ,细胞索紊乱 ,大部分肝窦消失 ,肝细胞呈中到重度水肿 ,多数细胞核体积缩小、深染 ,核膜轻度皱缩 ;丹参注射液治疗组小叶结构清晰 ,细胞索排列整齐 ,肝细胞损伤较轻 ,或仅有轻度浊肿及胞浆疏松。结论 :丹参注射液对大鼠酒精性肝损伤具有保护作用。 Objective: To observe the effect of Salvia miltiorrhiza injection on histopathology of alcoholic liver injury in rats, and to provide experimental basis for clinical treatment of alcoholic liver injury. METHODS: Rats were intragastrically modeled with white wine; normal diet and drinking water were used as controls; after treatment with Danshen injection, livers were obtained from each group, HE staining and light microscopy were performed. RESULTS: In the model group, the normal tissue of the liver disappeared, the boundary of the lobule was unclear, the cell line was disordered, most of the sinusoids disappeared, and the hepatocytes showed moderate to severe edema. Most of the nuclei were reduced in size and were deeply stained, and the nuclear membrane shrank slightly; Salvia miltiorrhiza injection The liquid treatment group had clear lobular structures, neatly arranged cell lines, lighter hepatic cell injury, or only mild edema and loose cytoplasm. Conclusion: Salvia miltiorrhiza injection has protective effect on alcoholic liver injury in rats.