【摘 要】
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The effects of porous hydroxyapatite blocks (PHABs) and an adjunct low-intensity pulsed ultrasound stimulation (LIPUS) on the fusion rate in a rabbit spinal pos
【机 构】
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Department of Spinal Surgery,Orthopedic Institute of Central South University,L(U) Hong-bin(Departme
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The effects of porous hydroxyapatite blocks (PHABs) and an adjunct low-intensity pulsed ultrasound stimulation (LIPUS) on the fusion rate in a rabbit spinal posterolateral fusion (PLF) model were evaluated. Twenty rabbits underwent PLF with autograft and PHABs were randomly assigned to two groups: treated group with 20 min LIPUS daily and untreated control group for 4 weeks until euthanasia. The fused motion segments were subjected to manual palpation, gross observation, and radiographic investigation before histomorphologic and scanning electron microscopic analyses. Statistical differences between the LIPUS group and the control group are found in the fusion rate, bone density gray scale, trabecular bone formation, osteoblast-like cells, chondrocytes and positive expression of BMP-2 and TGF-β1 in the junction zone (significance level p
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