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目的研究腰痛方剂在“性、味结合归经”层面上的配伍关系,揭示其内在规律。方法筛选古籍文献中治疗肾虚、寒湿和瘀血腰痛的方剂,信息标准化后建立Access数据库,量化处理每个方剂的性味归经,并以此为变量对每种证型的方剂分别聚类分析。结果每种腰痛方剂聚为5个主类时以性微温或温,味辛甘苦,归肾肝脾为主。药性组合特征:肾虚型:甘-微温-肾肝(63%);辛甘苦-微温-肝脾肾(23%);辛苦-温-肾脾(4%);辛甘-热-肾脾心(4%);苦甘-微寒-肾肝(3%)。寒湿型:苦辛-微温-肾肝(31%);辛甘-温-肾肝(26%);辛苦-温-脾胃(14%);甘-微温-肝肾(12%);甘-温-脾胃(11%)。瘀血型:辛苦-微温-肝(27%);甘苦-微温-肾肝(23%);辛甘-温-肝肾(21%);辛苦-微温-脾肾肝(13%);辛-温-肝脾(7%)。结论方剂的组合药性聚类能够反映治则治法的科学内涵,可为配伍规律的研究提供新思路。
Objective To study the compatibility of low back pain prescriptions on the level of “sex and taste combination”, reveal its internal rules. Methods The prescriptions for treating kidney deficiency, cold and blood stasis and low back pain were screened from the ancient literature. After the information was standardized, an Access database was established to quantify the flavor of each prescription and to classify the prescriptions of each syndrome as variables analysis. Results Each lumbago prescription gathered in five main categories of mild temperature or warm, bitter and bitter, mainly by the liver and spleen. Pharmacological combination characteristics: kidney type: Gan - tepid - kidney (63%); Xin Gan bitter - tepid liver and spleen and kidney (23% (4%); bitter Gan - slightly cold - kidney (3%). Cold and wet type: bitter Xin - tepid - kidney (31%); Xin Gan - warm - kidney (26%); hard - warm - spleen and stomach - warm - stomach (11%). (23%); Xin Gan - warm - liver and kidney (21%); hard - tepid - spleen and kidney (13%); symplectic - Warm - liver and spleen (7%). Conclusion The combination of prescriptions can reflect the scientific connotation of the rule of governance and provide new ideas for the study of compatibility rules.