论文部分内容阅读
目的观察分析联合普罗布考和阿托伐他汀对脑梗死患者脂代谢的影响。方法选取2012年10月-2015年5月医院收治的脑梗死患者110例,随机分为对照组和治疗组各55例。对照组仅用阿托伐他汀治疗,治疗组联合应用阿托伐他汀和普罗布考治疗,2组患者治疗疗程均为3个月。对比分析2组患者治疗效果、血脂以及高敏C反应蛋白水平。结果经3个月的治疗,治疗组和对照组比较,前者治疗效果显著,总胆固醇、高敏C-反应蛋白、低密度脂蛋白胆固醇、三酰甘油及氧化低密度脂蛋白水平低,高密度脂蛋白胆固醇水平高,差异有统计学意义(P<0.05)。结论联合应用普罗布考和阿托伐他汀治疗脑梗死,具有显著的抗氧化和抗脂作用,近期效果明显,值得应用。
Objective To observe the effect of combination of probucol and atorvastatin on lipid metabolism in patients with cerebral infarction. Methods A total of 110 patients with cerebral infarction admitted from October 2012 to May 2015 in our hospital were randomly divided into control group and treatment group (n = 55). The control group was treated with atorvastatin only. The treatment group was treated with atorvastatin and probucol, and both groups were treated for 3 months. The therapeutic effects, blood lipids and high-sensitivity C-reactive protein levels were compared between the two groups. Results After 3 months of treatment, the treatment group and the control group had significant therapeutic effect. The total cholesterol, high-sensitivity C-reactive protein, low-density lipoprotein cholesterol, triglyceride and oxidized low-density lipoprotein were low, High levels of protein cholesterol, the difference was statistically significant (P <0.05). Conclusion Combined use of probucol and atorvastatin in the treatment of cerebral infarction has significant anti-oxidation and anti-lipid effects, the recent results are obvious and worthy of application.