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近年来随着对潘生丁药理学研究的进展,其临床应用日趋广泛,对病毒感染性疾病的临床治疗观察的报道亦日益增多,本文根据我院儿科的临床观察和文献报道,仅对其在儿科抗病毒活性的临床应用作一概述。一、药理作用:试验证明潘生丁具有广谱抗病毒活性,主要对抗 RNA 病毒,如柯萨奇,灰髓炎野生株Ⅰ和Ⅱ型,减毒株Ⅲ型,埃可病毒6、11、30,鼻病毒Ⅰ型 A组等,流感病毒,正粘液病毒及某些 DNA 病毒。其作用机理主要为阻止尿苷、嘧啶核苷、腺苷及脱氧胞嘧啶核苷等进入细胞内,
In recent years, with the progress of the research on the pharmacology of dipyridamole, its clinical application is more and more widely, and the reports of the clinical treatment of viral infectious diseases are also increasing. According to the clinical observation and literature of pediatrics in our hospital, An overview of the clinical application of antiviral activity. First, the pharmacological effects: The test proved that dipyridamole has a broad spectrum of antiviral activity, mainly against RNA viruses such as coxsackie, gray myxoma wild type Ⅰ and Ⅱ, attenuated type Ⅲ, echovirus 6,11,30, Rhinovirus type I group A, etc., influenza virus, orthomyxovirus and some DNA viruses. Its mechanism of action is mainly to prevent uridine, pyrimidine nucleoside, adenosine and deoxycytidine into the cell,