论文部分内容阅读
目的探讨大剂量丙种球蛋白联合糖皮质激素治疗急性格林巴利综合征(GBS)的临床效果。方法选择洛阳市洛阳新区人民医院自2010年1月至2015年1月期间收治的64例急性GBS患者为研究对象并按照随机数字表法分为对照组和研究组,每组各32例。对照组患者给予大剂量丙种球蛋白治疗,研究组患者予大剂量丙种球蛋白联合糖皮质激素治疗。比较两组患者治疗后的临床效果以及两组间腱反射、四肢肌力恢复时间以及呼吸肌麻痹时间差异。结果研究组患者两组患者腱反射、四肢肌力恢复时间和呼吸肌麻痹时间均明显小于对照组患者,差异均有统计学意义(均P<0.05)。治疗后研究组患者总有效率明显高于对照组,差异有统计学意义(96.88%vs 84.38%,P<0.05)。结论大剂量丙种球蛋白联合糖皮质激素治疗急性格林巴利综合征能够明显缩短肌力恢复时间,效果明显优于单用丙种球蛋白,值得在临床中推广应用。
Objective To investigate the clinical effect of high-dose gamma globulin combined with glucocorticoid in the treatment of acute Guillain-Barre syndrome (GBS). Methods Sixty-four patients with acute GBS admitted from January 2010 to January 2015 in Luoyang New District People’s Hospital of Luoyang were selected as study subjects and divided into control group and study group according to random number table method, with 32 cases in each group. Patients in the control group were given high-dose gamma-globulin, and patients in the study group were given high-dose gamma-globulin in combination with glucocorticoid. The clinical effects of the two groups after treatment were compared, as well as the differences of tendon reflexes, recovery time of muscle strength of the limbs and paralysis of respiratory muscles between the two groups. Results The tendon reflexes, muscle strength recovery time and respiration muscle paralysis time of the two groups in the study group were significantly less than those in the control group (all P <0.05). After treatment, the total effective rate of the study group was significantly higher than that of the control group (96.88% vs 84.38%, P <0.05). Conclusion High-dose gamma globulin combined with glucocorticoid in the treatment of acute Guillain-Barre syndrome can shorten the muscle strength recovery time obviously, and the effect is better than that of gamma globulin alone. It is worth to be popularized in clinical practice.