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【目的】探析养血清脑颗粒联合帕罗西汀治疗情绪障碍性失眠症患者的效果及其作用机制。【方法】选取2013年4月至2015年10月本院所收治的情绪障碍性失眠症患者80例作为研究对象，按照就诊先后顺序编号分为观察组与对照组，各40例。对照组应用盐酸帕罗西汀进行治疗，观察组在对照组基础上联合养血清脑颗粒，比较两组治疗总有效率、治疗前后匹兹堡睡眠质量指数（PSQI）、汉密尔顿焦虑量表评分（HAMA）及药物不良反应发生率。【结果】观察组治疗总有效率为92．5％（37／40），高于对照组75．0％（30／40），差异有统计学意义（ P＜0．05）。两组治疗前、治疗2周及4周后的 PSQI 评分与治疗前、治疗2周后的 HAMA 评分均无显著差异，观察组治疗8周后的 PSQI 评分及治疗4周及8周后的 HAMA 评分均低于对照组，差异有统计学意义（ P ＜0．05）。观察组与对照组不良反应发生率分别为12．5％、10．0％，差异无统计学意义（ P ＞0．05）。【结论】养血清脑颗粒联合帕罗西汀治疗情绪障碍性失眠症具有理想效果，与单纯西药治疗相比，患者睡眠质量与情绪障碍改善幅度均更大，且安全性高。“,”Objective]To explore the effects of Yangxueqingnao Granule combined with paroxetine in the treatment of insomnia induced by emotional disorder and its mechanism of action .[Methods] A total of 80 cases of patients with in‐somnia induced by emotional disorder who were admitted to our hospital between April 2013 and October 2015 were se‐lected as study subjects .According to the order of treatment ,the patients were numbered and divided into an observation group and a control group ,with 40 cases in each .Patients in the control group were treated with paroxetine hydrochloride treatment ,while patients in the observation group were treated with paroxetine hydrochloride treatment in combination with Yangxueqingnao Granule .The total effective rate of treatment ,the Pittsburgh Sleep Quality Index (PSQI) score be‐fore and after treatment ,the Hamilton Anxiety Scale (HAMA) score ,and the incidence of adverse drug reactions were compared between the two groups .[Results] The total effective rate of treatment in the observation group [92 .5% (37/40)] was higher than that in the control group [75% (30/40)]( P 0 .05) in both groups ..The PSQI score in the observation group after 8 weeks of treatment and HAMA scores after 4 and 8 weeks of treatment were lower than those of the control group ( P 0 .05) .[Conclusion]Yangxueqingnao granule combined with paroxetine has the ideal effect on the treatment of insomnia induced by emotional disorder .Compared to pure western medicine treatment ,the im‐provement magnitudes of sleep quality and mental state are relatively greater and with high safety .