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肠出血性大肠杆菌O157∶H7能引起出血性结肠炎、溶血性尿毒综合征、血小板减少性紫癜等。大肠杆菌O157∶H7的主要毒力因子紧密黏附素由其毒力岛LEE岛上的eae基因编码,C末端的280个氨基酸是受体结合位点。目前发现紧密黏附素受体有紧密黏附素转位受体(Tir)、核仁素和β1整合素。紧密黏附素主要与受体Tir结合,通过Ⅲ型分泌系统转位到宿主细胞,在Tir-细胞骨架偶联蛋白(Tccp)的参与下,与N-Wiskott aldrich综合征蛋白、肌动蛋白-相关蛋白2/3相互作用产生信号级联放大,导致宿主大肠黏膜上产生黏附-抹去损伤。
Enterohemorrhagic Escherichia coli O157: H7 can cause hemorrhagic colitis, hemolytic uremic syndrome, thrombocytopenic purpura and so on. The major virulence factor of E. coli O157: H7 Tight adhesin is encoded by the eae gene on the LEE island of its virulent island, and the 280 amino acids at the C-terminus are receptor binding sites. Tight adhesin receptors are now found to have tight adhesion translocations (Tir), nucleotides, and β1 integrins. Tight adhesin binds mainly to the receptor Tir and translocates to the host via the type III secretion system and is involved in the N-Wiskott aldrich syndrome protein, actin-associated with the involvement of the Tir-cytoskeleton-associated protein (Tccp) The protein 2/3 interaction produces a signal cascade that results in adherence on the host colorectal mucosa - erasing the lesions.