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设计合成了4个9-卤代的前列腺素衍生物,经红外、核磁、质谱等确证其结构.药理试验表明,化合物1、2对大鼠离体子宫的收缩活性与米索前列醇相似;化合物3、4则无活性.
Four 9-halogenated prostaglandin derivatives were designed and synthesized, and their structures were confirmed by IR, NMR and MS.Pharmacological tests showed that compounds 1 and 2 had similar contractile activity to misoprostol in isolated rat uterus. Compounds 3 and 4 are inactive.