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黄杨科植物小叶黄杨中提得环维黄杨星—D(Cyclovirobuxine—D,简称CVB),在低浓度时(10~(-5)—3×10~(-5)M)对反映房室结内传导时间的 AH 有明显延长作用,对反映心室内传导时间的 HV 亦有一定延长,但没有 AH 延长明显。高浓度时(10~(-4)M—3×10~(-4)M)AH 及 HV 时间均有明显延长,在一定剂量范围内呈剂量依赖关系。CVB 使APD 延长,尤其2相斜率增大,2相显著延长,提示可能明显改变 Ca~(++)Isi 的失活过程。根据 CVB 对心脏电生理学的作用分析,可使心肌细胞的 APD 及 ERP 延长,并使 AH、HV 延长,而对 Vmax 及 AMP 无明显影响,可能拟似第三类抗心律失常药。
Cyclovirobuxine-D (CVB), Cyclovirobuxine-D (CVB) in Cyclovirobuxine, which reflects the atrioventricular node at low concentrations (10~(-5)–3x10~(-5)M) AH in the conduction time has a prolonged effect, and it also has a certain extension of the HV that reflects the conduction time in the heart, but there is no obvious extension of AH. At high concentrations (10~(-4)M - 3x10~(-4)M) AH and HV time were significantly prolonged, and dose-dependent within a certain dose range. CVB prolongs APD, especially the slope of phase 2 increases, and phase 2 significantly prolongs, suggesting that the inactivation process of Ca~(++)Isi may be significantly changed. According to the analysis of the effects of CVB on cardiac electrophysiology, APD and ERP in myocardial cells can be prolonged, and AH and HV can be prolonged without significant effects on Vmax and AMP, which may be similar to the third type of antiarrhythmic drugs.