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大分子抗肿瘤抗生素是抗肿瘤抗生素中一个大的家族。到目前为止,已发现近80余种。这类抗生素多由链霉菌产生,分子量在9000～15000道尔顿左右。它们均为110个左右的常见氨基酸所组成的蛋白部分及其所携带的一个或多个发色团所组成。由于其蛋白属性,本文亦称之为蛋白类抗肿瘤抗生素。该类抗生素多呈水溶性,对温度、碱和光线敏感。它们除了对许多实验性肿瘤都有效外,有些还具有不同程度的抗细菌活性,另有一些还有一定的抗病毒作用。在这类抗肿瘤抗生素中,Neocarzinostatin(NCS)、Macromomycin(MCR)、Actinoxanthin(AXN)、Sporamycin、Auromomycin和C-1027等是研究得较为广泛和深入
Macromolecular antitumor antibiotics are a large family of antitumor antibiotics. So far, nearly 80 species have been found. Such antibiotics are mostly produced by Streptomyces, the molecular weight of 9000 ~ 15000 Daltons. They are composed of about 110 common amino acids and the protein part of one or more chromophores carried by them. Due to its protein properties, this article is also referred to as protein antitumor antibiotics. Most of these antibiotics are water-soluble, temperature, alkali and light sensitive. In addition to their effectiveness in many experimental tumors, some have varying degrees of antibacterial activity, while others have some antiviral activity. Among these antitumor antibiotics, Neocarzinostatin (NCS), Macromomycin (MCR), Actinoxanthin (AXN), Sporamycin, Auromomycin and C-1027 are widely studied and widely studied