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目的:探讨裸花紫珠胶囊治疗牙周炎的临床疗效。方法:选择84例患者,共160颗患牙,随机分为治疗组和对照组,治疗组用龈下刮治和根面平整术(SRP)+口服裸花紫珠胶囊一次0.8g,每日3次治疗,对照组用龈下刮治和根面平整术(SRP)+口服甲硝唑片一次0.4g,每日3次治疗,比较两组疗效和药物不良反应。结果:治疗组显效率75.0%(60/80),好转率21.3%(17/80),总有效率为96.3%(77/80),对照组显效率61.3%(49/80),好转率17.5%(14/80),总有效率为78.8%(63/80),两组比较差异显著(P<0.05);两组患者牙龈指数(GI)、牙周袋深度(PD)和牙龈出血指数(SBI)均明显下降,但治疗组变化幅度更大,差异有统计学意义(P<0.05);治疗组副反应发生率为13.7%,对照组副反应发生率为42.9%,两组比较差异有统计学意义(P<0.05)。结论:裸花紫珠胶囊治疗牙周炎疗效确切,不良反应较少,值得在临床推广应用。
Objective: To investigate the clinical curative effect of naked flower violet capsule on periodontitis. Methods: A total of 160 patients with 84 teeth were selected and randomly divided into treatment group and control group. The treatment group was treated with SRP + oral Bupleurum Capsule 0.8g once daily 3 treatments, the control group with subgingival curettage and root planing (SRP) + oral metronidazole tablets 0.4g, 3 times a day treatment, the two groups were compared efficacy and adverse drug reactions. Results: The effective rate of the treatment group was 75.0% (60/80), the improvement rate was 21.3% (17/80), the total effective rate was 96.3% (77/80), the control group markedly effective rate was 61.3% (49/80) The total effective rate was 78.8% (63/80) in the two groups (P <0.05). The Gingival Index (GI), Periodontal Pocket Depth (PD) and Gingival Bleeding Index (SBI) were significantly decreased, but the treatment group greater changes, the difference was statistically significant (P <0.05); the incidence of side effects in the treatment group was 13.7%, the incidence of side effects in the control group was 42.9% The difference was statistically significant (P <0.05). Conclusion: The treatment of periodontitis with the naked flower violet capsule has definite effect and few adverse reactions, which is worth popularizing and applying in clinic.