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分析杂合性急性白血病(hybrid acute leukemia, HAL)的临床、细胞形态、细胞化学、免疫学及细胞遗传学特征,以了解其临床意义。方法:选择1991年10月至1996年8月间我院治疗的成人急性白血病患者145例,采用瑞特染色、常规细胞化学染色、间接免疫荧光、G显带方法,按Catovsky标准,凡淋巴和髓系积分均≥2分者诊为HAL。结果:9例(9/145)患者诊为HAL,临床表现无特征性异常,细胞形态及细胞化学染色多显示淋巴或髓系特征,免疫学表型多同时显示两系标志,5例核型异常,完全缓解(complete remission, CR)者 3例(3/9),与其余 136例急性白血病患者CR率(69.85%)相比.有明显统计学差异(P<0.05)。结论;免疫分型技术在HAL诊断中可发挥重要作用。
To analyze the clinical, cellular morphology, cytochemistry, immunology, and cytogenetic features of hybrid acute leukemia (HAL) to understand its clinical significance. METHODS: One hundred and forty-five adult acute leukemia patients treated in our hospital between October 1991 and August 1996 were selected and treated with Reiter’s staining, conventional cytochemical staining, indirect immunofluorescence, and G banding methods. Patients with ≥2 points of myeloid scores were diagnosed as HAL. Results: Nine patients (9/145) were diagnosed as HAL with no characteristic clinical abnormalities. Cytomorphology and cytochemical staining showed lymphatic or myeloid features. Immunophenotypic phenotypes showed multiple signs at the same time. Five cases were karyotypes. Abnormalities and complete remission (CR) were found in 3 (3/9) patients, which was significantly different from the CR rate (69.85%) in the remaining 136 patients with acute leukemia (P<0.05). Conclusion; Immunophenotyping technology can play an important role in the diagnosis of HAL.