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为初步探讨前列腺增生（ＢＰＨ）的射频热疗机理，对１１例射频热疗后和１２例未行射频热疗的人前列腺标本的病理组织学和前列腺特异性抗原（ＰＳＡ）免疫组化表达进行观察。结果表明：射频可使邻近尿道的前列腺组织变性坏死、平滑肌断裂、ＰＳＡ表达明显减弱，然后纤维组织增生修复，对射频热疗机理及影响临床疗效的有关因素进行了初步讨论，认为射频热疗既可通过前列腺实质坏死、组织修复来扩大尿道内腔，亦可通过破坏或阻断前列腺组织中α－受体以及前列腺平滑肌变性坏死来减轻ＢＰＨ的动力性因素；射频热疗对前列腺体积相对较小的ＢＰＨ患者不适宜。
To investigate the mechanism of radiofrequency hyperthermia in benign prostatic hyperplasia (BPH), the histopathology and PSA immunohistochemistry of 11 cases of radiofrequency ablation and 12 cases of human prostate without radiofrequency ablation were performed Observed. The results showed that RF could degeneration and necrosis of the prostate tissue adjacent to the urethra, smooth muscle rupture, PSA expression was significantly weakened, and then the proliferation of fibrous tissue repair, radiofrequency hyperthermia mechanism and the factors that affect the clinical efficacy of a preliminary discussion, that radiofrequency thermotherapy both Prostate parenchyma can be necrosis, tissue repair to expand the urinary tract lumen, but also by disrupting or blocking prostate tissue α-receptor and prostatic smooth muscle degeneration and necrosis to reduce the dynamic factors of BPH; RFH to prostate volume is relatively small Of BPH patients is not appropriate.