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采用麻醉大鼠左冠状动脉前降支结扎及结扎5min后再开放,造成心肌缺血和缺血/再灌流损伤的模型,观察了粉防己碱(Tet)对心肌缺血及再灌流所诱发的心律失常的作用。静脉注射Tet 4mg·kg~(-1)后可明显降低心肌缺血及再灌流损伤所诱发的心律失常严重程度。
Anesthetized rats left anterior descending coronary artery ligation and ligation 5min and then open, resulting in myocardial ischemia and ischemia / reperfusion injury model was observed tetrandrine (Tet) on myocardial ischemia and reperfusion induced The role of arrhythmia. Intravenous Tet 4 mg · kg -1 can significantly reduce the severity of arrhythmia induced by myocardial ischemia and reperfusion injury.