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本研究应用放射免疫法观察新生儿缺氧缺血性脑病（HIE）时血浆内皮素（ET）及心钻素（ANP）的动态变化，同时测定血清钙、钠等电解质浓度水平，并与正常新生儿组进行对照。结果表明HIE患儿血浆ET、ANP含量明显高于对照组，而血清钙、钠水平则低于对照组；随病情恢复过程ET及ANP逐渐下降伴血钙、钠浓度上升；病情轻重程度与各项指标变化差异及恢复时间有相关关系，提示ET与ANP参与HIE的病理生理过程。ET对血管作用主要通过钙调节机制，ANP通过钙拮抗机制对抗ET的生物学效应，因此在ET增加时ANP的增多可能是机体自稳态调节功能的表现。
In this study, the dynamic changes of plasma endothelin (ET) and cardiac amniotic fluid (ANP) in neonatal hypoxic-ischemic encephalopathy (HIE) were observed by radioimmunoassay. The concentrations of electrolytes such as serum calcium and sodium were measured simultaneously with normal Neonates were compared. The results showed that the levels of plasma ET and ANP in children with HIE were significantly higher than those in the control group, while the levels of serum calcium and sodium were lower than those in the control group. With the gradual decline of ET and ANP, There was a correlation between the index changes and recovery time, suggesting that ET and ANP participate in the pathophysiological process of HIE. The effect of ET on blood vessels is mainly through the mechanism of calcium regulation. ANP antagonizes the biological effects of ET through calcium antagonism mechanism. Therefore, the increase of ANP may be the manifestation of autophagic regulatory function of body.